D81.8Other combined immunodeficiencies

D81.8 is the ICD-10-CM diagnosis code for other combined immunodeficiencies. It belongs to category D81 (combined immunodeficiencies), block D80-D89 (certain disorders involving the immune mechanism) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.

Within D81, choose D81.8 (Other combined immunodeficiencies) only when documentation doesn't support a more specific option: severe combined immunodeficiency [SCID] with reticular dysgenesis (D81.0), severe combined immunodeficiency [SCID] with low T- and B-cell numbers (D81.1), severe combined immunodeficiency [SCID] with low or normal B-cell numbers (D81.2), adenosine deaminase [ADA] deficiency (D81.3), Nezelof's syndrome (D81.4), purine nucleoside phosphorylase [PNP] deficiency (D81.5), major histocompatibility complex class I deficiency (D81.6), major histocompatibility complex class II deficiency (D81.7) and 1 more.

To report this condition, pick the subcode that matches the documentation: D81.81 (deficiency), D81.82 ([APDS]) and D81.89 (immunodeficiencies).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.