D81.3Adenosine deaminase [ADA] deficiency

D81.3 is the ICD-10-CM diagnosis code for adenosine deaminase [ADA] deficiency. It belongs to category D81 (combined immunodeficiencies), block D80-D89 (certain disorders involving the immune mechanism) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 4 subcodes must be used instead.

Within D81 (combined immunodeficiencies), D81.3 is specifically for adenosine deaminase [ADA] deficiency. Related codes cover severe combined immunodeficiency [SCID] with reticular dysgenesis (D81.0), severe combined immunodeficiency [SCID] with low T- and B-cell numbers (D81.1), severe combined immunodeficiency [SCID] with low or normal B-cell numbers (D81.2), Nezelof's syndrome (D81.4), purine nucleoside phosphorylase [PNP] deficiency (D81.5), major histocompatibility complex class I deficiency (D81.6), major histocompatibility complex class II deficiency (D81.7), other combined immunodeficiencies (D81.8) and 1 more.

To report this condition, pick the subcode that matches the documentation: D81.30 (unspecified), D81.31 (deficiency), D81.32 (deficiency) and D81.39 (deficiency).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2020 (expanded into subcodes).

Before ICD-10, this condition was coded in ICD-9-CM as 277.2 (other disorders of purine and pyrimidine metabolism).