D89.83Cytokine release syndrome

D89.83 is the ICD-10-CM diagnosis code for Cytokine release syndrome. It belongs to category D89 (other disorders involving the immune mechanism, not elsewhere classified), block D80-D89 (certain disorders involving the immune mechanism) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 6 subcodes must be used instead.

Within D89.8 (other specified disorders involving the immune mechanism, not elsewhere classified), D89.83 is specifically for Cytokine release syndrome. Related codes cover graft-versus-host disease (D89.81), autoimmune lymphoproliferative syndrome [ALPS] (D89.82), IgG4-related disease (D89.84) and other specified disorders involving the immune mechanism, not elsewhere classified (D89.89).

To report this condition, pick the subcode that matches the documentation: D89.831 (grade 1), D89.832 (grade 2), D89.833 (grade 3), D89.834 (grade 4), D89.835 (grade 5) and D89.839 (grade unspecified).

Code first underlying cause, such as: complications following infusion, transfusion and therapeutic injection (T80.89-) and complications of transplanted organs and tissue (T86.-).

Use an additional code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5). Use an additional code to identify associated manifestations.

It was added in FY2021, effective October 1, 2020.