E83.820Generalized arterial calcification of infancy with unspecified genetic causality

E83.820 is the ICD-10-CM diagnosis code for generalized arterial calcification of infancy with unspecified genetic causality. It belongs to category E83 (disorders of mineral metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E83.82, choose E83.820 (Generalized arterial calcification of infancy with unspecified genetic causality) only when documentation doesn't support a more specific option: ENPP1 deficiency causing generalized arterial calcification of infancy (E83.821), ENPP1 deficiency causing autosomal recessive hypophosphatemic rickets type 2 (E83.822), ABCC6 deficiency causing generalized arterial calcification of infancy (E83.823), ABCC6 deficiency causing pseudoxanthoma elasticum (E83.824) and CD73 deficiency causing arterial calcification (E83.825).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 299 (Peripheral Vascular Disorders with MCC, relative weight 1.5842), DRG 300 (Peripheral Vascular Disorders with CC, relative weight 1.0464), DRG 301 (Peripheral Vascular Disorders without CC/MCC, relative weight 0.7133), DRG 791 (Prematurity with Major Problems, relative weight 4.1075) and DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), in MDC 05 (Diseases and Disorders of the Circulatory System) and MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It was added in FY2026, effective October 1, 2025.