E83.825CD73 deficiency causing arterial calcification

E83.825 is the ICD-10-CM diagnosis code for CD73 deficiency causing arterial calcification. It belongs to category E83 (disorders of mineral metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E83.82 (disorders of pyrophosphate metabolism), E83.825 is specifically for CD73 deficiency causing arterial calcification. Related codes cover generalized arterial calcification of infancy with unspecified genetic causality (E83.820), ENPP1 deficiency causing generalized arterial calcification of infancy (E83.821), ENPP1 deficiency causing autosomal recessive hypophosphatemic rickets type 2 (E83.822), ABCC6 deficiency causing generalized arterial calcification of infancy (E83.823) and ABCC6 deficiency causing pseudoxanthoma elasticum (E83.824).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 299 (Peripheral Vascular Disorders with MCC, relative weight 1.5842), DRG 300 (Peripheral Vascular Disorders with CC, relative weight 1.0464) and DRG 301 (Peripheral Vascular Disorders without CC/MCC, relative weight 0.7133), in MDC 05 (Diseases and Disorders of the Circulatory System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It was added in FY2026, effective October 1, 2025.