ICD-10-CM 2027
ICD-10 code for glycine metabolism disorder
From the official ICD-10-CM alphabetic index entry “Disorder (of) › glycine metabolism”. Page updated September 29, 2026.
About coding glycine metabolism disorder
The ICD-10-CM code for glycine metabolism disorder is E72.50 (Disorder of glycine metabolism, unspecified). The official index lists 18 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E72.50.
Within E72.5, choose E72.50 (Disorder of glycine metabolism, unspecified) only when documentation doesn't support a more specific option: Non-ketotic hyperglycinemia (E72.51), Trimethylaminuria (E72.52), primary hyperoxaluria (E72.53), secondary hyperoxaluria (E72.54) and other disorders of glycine metabolism (E72.59).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific glycine metabolism disorder codes (official index)
- d-glycericacidemia E72.59 — Other disorders of glycine metabolism
- hyperhydroxyprolinemia E72.59 — Other disorders of glycine metabolism
- hyperoxaluria R82.992 — Hyperoxaluria
- dietary E72.540 — Dietary hyperoxaluria
- enteric E72.541 — Enteric hyperoxaluria
- primary E72.539 — Primary hyperoxaluria, unspecified
- specified type NEC E72.538 — Other specified primary hyperoxaluria
- type 1 E72.530 — Primary hyperoxaluria, type 1
- type 2 E72.538 — Other specified primary hyperoxaluria
- type 3 E72.538 — Other specified primary hyperoxaluria
- secondary E72.549 — Secondary hyperoxaluria, unspecified
- specified type NEC E72.548 — Other secondary hyperoxaluria
- hyperprolinemia E72.59 — Other disorders of glycine metabolism
- non-ketotic hyperglycinemia E72.51 — Non-ketotic hyperglycinemia
- oxalosis E72.53 — Primary hyperoxaluria
- oxaluria E72.53 — Primary hyperoxaluria
- sarcosinemia E72.59 — Other disorders of glycine metabolism
- trimethylaminuria E72.52 — Trimethylaminuria
Common questions about glycine metabolism disorder ICD-10 codes
What is the ICD-10 code for glycine metabolism disorder?
- E72.50 — Disorder of glycine metabolism, unspecified. More specific codes apply when the documentation supports them: E72.59, E72.59, R82.992, E72.540 and others below.
What is the ICD-10 code for d-glycericacidemia glycine metabolism disorder?
- E72.59 — Other disorders of glycine metabolism.
What is the ICD-10 code for hyperhydroxyprolinemia glycine metabolism disorder?
- E72.59 — Other disorders of glycine metabolism.
What is the ICD-10 code for hyperoxaluria glycine metabolism disorder?
- R82.992 — Hyperoxaluria.
What is the ICD-10 code for hyperprolinemia glycine metabolism disorder?
- E72.59 — Other disorders of glycine metabolism.
What is the ICD-10 code for non-ketotic hyperglycinemia glycine metabolism disorder?
- E72.51 — Non-ketotic hyperglycinemia.
What is the ICD-10 code for oxalosis glycine metabolism disorder?
- E72.53 — Primary hyperoxaluria (header code; choose a more specific subcode).
Is E72.50 billable?
- Yes. E72.50 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E72.50 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E72.50 as a principal diagnosis.
Is E72.50 a CC or MCC?
- E72.50 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.