E72.59Other disorders of glycine metabolism

E72.59 is the ICD-10-CM diagnosis code for other disorders of glycine metabolism. It belongs to category E72 (other disorders of amino-acid metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E72.5, choose E72.59 (Other disorders of glycine metabolism) only when documentation doesn't support a more specific option: disorder of glycine metabolism, unspecified (E72.50), Non-ketotic hyperglycinemia (E72.51), Trimethylaminuria (E72.52), primary hyperoxaluria (E72.53) and secondary hyperoxaluria (E72.54).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 270.7 (other disturbances of straight-chain amino-acid metabolism).