E72.53Primary hyperoxaluria

E72.53 is the ICD-10-CM diagnosis code for primary hyperoxaluria. It belongs to category E72 (other disorders of amino-acid metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.

Within E72.5 (disorders of glycine metabolism), E72.53 is specifically for primary hyperoxaluria. Related codes cover disorder of glycine metabolism, unspecified (E72.50), Non-ketotic hyperglycinemia (E72.51), Trimethylaminuria (E72.52), secondary hyperoxaluria (E72.54) and other disorders of glycine metabolism (E72.59).

To report this condition, pick the subcode that matches the documentation: E72.530 (type 1), E72.538 (hyperoxaluria) and E72.539 (unspecified).

Don't report E72.53 together with the conditions in its Excludes1 note: secondary hyperoxaluria (E72.54-).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2019 (title revised) and FY2026 (expanded into subcodes).

Before ICD-10, this condition was coded in ICD-9-CM as 271.8 (other specified disorders of carbohydrate transport and metabolism).