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ICD-10-CM 2027 diagnosis code

E72.538Other specified primary hyperoxaluria

✓ Billable / specificCC — complication/comorbidity

E72.538 is a valid, billable ICD-10-CM code for other specified primary hyperoxaluria. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code last changed in FY2026 (effective October 1, 2025). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E72.538

E72.538 is the ICD-10-CM diagnosis code for other specified primary hyperoxaluria. It belongs to category E72 (other disorders of amino-acid metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E72.53, choose E72.538 (Other specified primary hyperoxaluria) only when documentation doesn't support a more specific option: type 1 (E72.530) and unspecified (E72.539).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It was added in FY2026, effective October 1, 2025.

Coding notes

Applicable toConditions and synonyms classified to this code
  • Primary hyperoxaluria, type 2
  • Primary hyperoxaluria, type 3

Notes that apply from higher levels

Instructions written at a parent level also apply to E72.538.

› From E72.53 Primary hyperoxaluria
Excludes1
› From E72 Other disorders of amino-acid metabolism
Excludes1
  • disorders of:
  • aromatic amino-acid metabolism (E70.-)
  • branched-chain amino-acid metabolism (E71.0-E71.2)
  • fatty-acid metabolism (E71.3)
  • purine and pyrimidine metabolism (E79.-)
  • gout (M1A.-, M10.-)

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

3 entries

Terms in the official ICD-10-CM index that lead to E72.538.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2026 (effective 10/1/2025): Added
  • No changes since FY2026.

Common questions about E72.538

Is E72.538 billable?

Yes. E72.538 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E72.538 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E72.538 as a principal diagnosis.

Is E72.538 a CC or MCC?

E72.538 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does E72.538 group to?

E72.538 is used in the MS-DRG v44.0 logic for MS-DRG 642 (Inborn and Other Disorders of Metabolism). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.