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ICD-10-CM 2027 diagnosis code

E72.540Dietary hyperoxaluria

✓ Billable / specific

E72.540 is a valid, billable ICD-10-CM code for dietary hyperoxaluria. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code last changed in FY2026 (effective October 1, 2025). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E72.540

E72.540 is the ICD-10-CM diagnosis code for dietary hyperoxaluria. It belongs to category E72 (other disorders of amino-acid metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E72.54 (secondary hyperoxaluria), E72.540 is specifically for dietary hyperoxaluria. Related codes cover Enteric hyperoxaluria (E72.541), other secondary hyperoxaluria (E72.548) and unspecified (E72.549).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 695 (Kidney and Urinary Tract Signs and Symptoms with MCC, relative weight 1.1139) and DRG 696 (Kidney and Urinary Tract Signs and Symptoms without MCC, relative weight 0.6679), in MDC 11 (Diseases and Disorders of the Kidney and Urinary Tract), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It was added in FY2026, effective October 1, 2025.

Notes that apply from higher levels

Instructions written at a parent level also apply to E72.540.

› From E72.54 Secondary hyperoxaluria
Excludes1
› From E72 Other disorders of amino-acid metabolism
Excludes1
  • disorders of:
  • aromatic amino-acid metabolism (E70.-)
  • branched-chain amino-acid metabolism (E71.0-E71.2)
  • fatty-acid metabolism (E71.3)
  • purine and pyrimidine metabolism (E79.-)
  • gout (M1A.-, M10.-)

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

1 entries

Terms in the official ICD-10-CM index that lead to E72.540.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2026 (effective 10/1/2025): Added
  • No changes since FY2026.

Common questions about E72.540

Is E72.540 billable?

Yes. E72.540 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E72.540 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E72.540 as a principal diagnosis.

Is E72.540 a CC or MCC?

No. E72.540 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E72.540 group to?

E72.540 is used in the MS-DRG v44.0 logic for MS-DRG 695 (Kidney and Urinary Tract Signs and Symptoms with MCC) and MS-DRG 696 (Kidney and Urinary Tract Signs and Symptoms without MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.