Skip to content
Dx

ICD-10-CM 2027 diagnosis code

E72.54Secondary hyperoxaluria

Not billable — use a more specific code

E72.54 is a header code, so it can't be reported by itself. Choose one of the 4 more specific codes beneath it.

Code last changed in FY2026 (effective October 1, 2025). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E72.54

E72.54 is the ICD-10-CM diagnosis code for secondary hyperoxaluria. It belongs to category E72 (other disorders of amino-acid metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 4 subcodes must be used instead.

Within E72.5 (disorders of glycine metabolism), E72.54 is specifically for secondary hyperoxaluria. Related codes cover disorder of glycine metabolism, unspecified (E72.50), Non-ketotic hyperglycinemia (E72.51), Trimethylaminuria (E72.52), primary hyperoxaluria (E72.53) and other disorders of glycine metabolism (E72.59).

To report this condition, pick the subcode that matches the documentation: E72.540 (hyperoxaluria), E72.541 (hyperoxaluria), E72.548 (hyperoxaluria) and E72.549 (unspecified).

Don't report E72.54 together with the conditions in its Excludes1 note: primary hyperoxaluria (E72.53-).

It was added in FY2026, effective October 1, 2025.

Specific codes under E72.54

Coding notes

Excludes1Not coded here — never report together with this code

Notes that apply from higher levels

Instructions written at a parent level also apply to E72.54.

› From E72 Other disorders of amino-acid metabolism
Excludes1
  • disorders of:
  • aromatic amino-acid metabolism (E70.-)
  • branched-chain amino-acid metabolism (E71.0-E71.2)
  • fatty-acid metabolism (E71.3)
  • purine and pyrimidine metabolism (E79.-)
  • gout (M1A.-, M10.-)

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Codes whose notes reference E72.54

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2026 (effective 10/1/2025): Added
  • No changes since FY2026.

Common questions about E72.54

Is E72.54 billable?

No. E72.54 is a header code. Report one of its more specific subcodes instead.