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ICD-10-CM 2027 diagnosis code

E72.3Disorders of lysine and hydroxylysine metabolism

✓ Billable / specificCC — complication/comorbidity

E72.3 is a valid, billable ICD-10-CM code for disorders of lysine and hydroxylysine metabolism. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Looking up by condition? See ICD-10 code for Hyperlysinemia, ICD-10 code for Saccharopinuria, ICD-10 code for Hydroxylysinemia, ICD-10 code for Glutaric aciduria.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E72.3

E72.3 is the ICD-10-CM diagnosis code for disorders of lysine and hydroxylysine metabolism. It belongs to category E72 (other disorders of amino-acid metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E72 (other disorders of amino-acid metabolism), E72.3 is specifically for disorders of lysine and hydroxylysine metabolism. Related codes cover disorders of amino-acid transport (E72.0), disorders of sulfur-bearing amino-acid metabolism (E72.1), disorders of urea cycle metabolism (E72.2), disorders of ornithine metabolism (E72.4), disorders of glycine metabolism (E72.5), other specified disorders of amino-acid metabolism (E72.8) and disorder of amino-acid metabolism, unspecified (E72.9).

Don't report E72.3 together with the conditions in its Excludes1 note: glutaric aciduria type II (E71.313), Refsum's disease (G60.1) and Zellweger syndrome (E71.510).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 270.7 (other disturbances of straight-chain amino-acid metabolism).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Glutaric aciduria NOS
  • Glutaric aciduria (type I)
  • Hydroxylysinemia
  • Hyperlysinemia
Excludes1Not coded here — never report together with this code

Notes that apply from higher levels

Instructions written at a parent level also apply to E72.3.

› From E72 Other disorders of amino-acid metabolism
Excludes1
  • disorders of:
  • aromatic amino-acid metabolism (E70.-)
  • branched-chain amino-acid metabolism (E71.0-E71.2)
  • fatty-acid metabolism (E71.3)
  • purine and pyrimidine metabolism (E79.-)
  • gout (M1A.-, M10.-)

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

14 entries

Terms in the official ICD-10-CM index that lead to E72.3.

Codes whose notes reference E72.3

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders

ICD-9-CM equivalent

Converter →
  • 270.7Other disturbances of straight-chain amino-acid metabolismapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E72.3

Is E72.3 billable?

Yes. E72.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E72.3 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E72.3 as a principal diagnosis.

Is E72.3 a CC or MCC?

E72.3 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does E72.3 group to?

E72.3 is used in the MS-DRG v44.0 logic for MS-DRG 642 (Inborn and Other Disorders of Metabolism). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E72.3?

The CMS General Equivalence Mappings map E72.3 to ICD-9-CM 270.7.