Skip to content
Dx

ICD-10-CM 2027 diagnosis code

E78.49Other hyperlipidemia

✓ Billable / specific

E78.49 is a valid, billable ICD-10-CM code for other hyperlipidemia. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code last changed in FY2019 (effective October 1, 2018). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E78.49

E78.49 is the ICD-10-CM diagnosis code for other hyperlipidemia. It belongs to category E78 (disorders of lipoprotein metabolism and other lipidemias), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E78.4, choose E78.49 (Other hyperlipidemia) only when documentation doesn't support a more specific option: elevated Lipoprotein(a) (E78.41).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It was added in FY2019, effective October 1, 2018.

Coding notes

Applicable toConditions and synonyms classified to this code
  • Familial combined hyperlipidemia

Notes that apply from higher levels

Instructions written at a parent level also apply to E78.49.

› From E78 Disorders of lipoprotein metabolism and other lipidemias
Excludes1

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

2 entries

Terms in the official ICD-10-CM index that lead to E78.49.

Codes whose notes reference E78.49

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2019 (effective 10/1/2018): Added
  • No changes since FY2019.

Common questions about E78.49

Is E78.49 billable?

Yes. E78.49 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E78.49 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E78.49 as a principal diagnosis.

Is E78.49 a CC or MCC?

No. E78.49 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E78.49 group to?

E78.49 is used in the MS-DRG v44.0 logic for MS-DRG 642 (Inborn and Other Disorders of Metabolism). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.