ICD-10-CM 2027 diagnosis code
E78.2Mixed hyperlipidemia
E78.2 is a valid, billable ICD-10-CM code for mixed hyperlipidemia. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Looking up by condition? See ICD-10 code for Xanthoma, ICD-10 code for Xanthelasmatosis, ICD-10 code for Betalipoproteinemia, ICD-10 code for Dysbetalipoproteinemia.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About E78.2
E78.2 is the ICD-10-CM diagnosis code for mixed hyperlipidemia. It belongs to category E78 (disorders of lipoprotein metabolism and other lipidemias), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within E78 (disorders of lipoprotein metabolism and other lipidemias), E78.2 is specifically for mixed hyperlipidemia. Related codes cover pure hypercholesterolemia (E78.0), pure hyperglyceridemia (E78.1), Hyperchylomicronemia (E78.3), other hyperlipidemia (E78.4), hyperlipidemia, unspecified (E78.5), lipoprotein deficiency (E78.6), disorders of bile acid and cholesterol metabolism (E78.7), other disorders of lipoprotein metabolism (E78.8) and 1 more.
Don't report E78.2 together with the conditions in its Excludes1 note: cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5) and familial combined hyperlipidemia (E78.49).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 272.2 (mixed hyperlipidemia).
Coding notes
- Broad- or floating-betalipoproteinemia
- Combined hyperlipidemia NOS
- Elevated cholesterol with elevated triglycerides NEC
- Fredrickson's hyperlipoproteinemia, type IIb or III
- Hyperbetalipoproteinemia with prebetalipoproteinemia
- Hypercholesteremia with endogenous hyperglyceridemia
- Hyperlipidemia, group C
- Tubo-eruptive xanthoma
- Xanthoma tuberosum
Notes that apply from higher levels
Instructions written at a parent level also apply to E78.2.
Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.
Alphabetic index entries
33 entriesTerms in the official ICD-10-CM index that lead to E78.2.
- Betalipoproteinemia, broad or floating
- Broad › beta disease
- Broad- or floating-betalipoproteinemia
- Cholesterol › elevated (high) › with elevated (high) triglycerides
- Cirrhosis, cirrhotic (hepatic) (liver) › due to › xanthomatosis
- Cirrhosis, cirrhotic (hepatic) (liver) › xanthomatous (biliary) › due to xanthomatosis (familial) (metabolic) (primary)
- Disease, diseased › broad › beta
- Dysbetalipoproteinemia (familial)
- Elevated, elevation › cholesterol › with high triglycerides
- Elevated, elevation › triglycerides › with high cholesterol
- Findings, abnormal, inconclusive, without diagnosis › cholesterol › high › with high triglycerides
- Findings, abnormal, inconclusive, without diagnosis › triglycerides › high › with high cholesterol
- Frederickson's hyperlipoproteinemia, type › IIB and III
- High › cholesterol › with high triglycerides
- High › triglycerides › with high cholesterol
- Hyperbetalipoproteinemia (familial) › with prebetalipoproteinemia
- Hypercholesterolemia (essential) (primary) (pure) › with hyperglyceridemia, endogenous
- Hyperlipemia, hyperlipidemia › combined
- Hyperlipemia, hyperlipidemia › group › C
- Hyperlipemia, hyperlipidemia › mixed
- Hyperlipoproteinemia › Fredrickson's type › IIb
- Hyperlipoproteinemia › Fredrickson's type › III
- Lipoproteinemia › broad-beta
- Lipoproteinemia › floating-beta
- Xanthelasmatosis (essential)
- Xanthoma (s), xanthomatosis (primary) (familial) (hereditary)
- Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › with › hyperlipoproteinemia › Type III
- Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › disseminatum (skin)
- Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › eruptive
- Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › multiple (skin)
- Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › tubo-eruptive
- Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › tuberosum
- Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › tuberous
Codes whose notes reference E78.2
- M67Excludes1
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders
ICD-9-CM equivalent
Converter →- 272.2Mixed hyperlipidemiaexact
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about E78.2
Is E78.2 billable?
- Yes. E78.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E78.2 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E78.2 as a principal diagnosis.
Is E78.2 a CC or MCC?
- No. E78.2 is neither a CC nor an MCC under MS-DRG v44.0.
What DRG does E78.2 group to?
- E78.2 is used in the MS-DRG v44.0 logic for MS-DRG 642 (Inborn and Other Disorders of Metabolism). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for E78.2?
- The CMS General Equivalence Mappings map E78.2 to ICD-9-CM 272.2.