E88.1Lipodystrophy, not elsewhere classified

E88.1 is the ICD-10-CM diagnosis code for lipodystrophy, not elsewhere classified. It belongs to category E88 (other and unspecified metabolic disorders), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 6 subcodes must be used instead.

Within E88 (other and unspecified metabolic disorders), E88.1 is specifically for lipodystrophy, not elsewhere classified. Related codes cover disorders of plasma-protein metabolism, not elsewhere classified (E88.0), Lipomatosis, not elsewhere classified (E88.2), tumor lysis syndrome (E88.3), mitochondrial metabolism disorders (E88.4), other specified metabolic disorders (E88.8), metabolic disorder, unspecified (E88.9) and wasting disease (syndrome) due to underlying condition (E88.A).

To report this condition, pick the subcode that matches the documentation: E88.10 (unspecified), E88.11 (lipodystrophy), E88.12 (lipodystrophy), E88.13 (lipodystrophy), E88.14 (lipodystrophy) and E88.19 (classified).

Don't report E88.1 together with the conditions in its Excludes1 note: Whipple's disease (K90.81).

Use an additional code for: codes for associated conditions.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2026 (expanded into subcodes).

Before ICD-10, this condition was coded in ICD-9-CM as 272.6 (lipodystrophy).