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ICD-10-CM 2027 diagnosis code

E88.3Tumor lysis syndrome

✓ Billable / specificMCC — major complication/comorbidity

E88.3 is a valid, billable ICD-10-CM code for tumor lysis syndrome. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Looking up by condition? See ICD-10 code for Tumor lysis syndrome NEC.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E88.3

E88.3 is the ICD-10-CM diagnosis code for tumor lysis syndrome. It belongs to category E88 (other and unspecified metabolic disorders), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E88 (other and unspecified metabolic disorders), E88.3 is specifically for tumor lysis syndrome. Related codes cover disorders of plasma-protein metabolism, not elsewhere classified (E88.0), lipodystrophy, not elsewhere classified (E88.1), Lipomatosis, not elsewhere classified (E88.2), mitochondrial metabolism disorders (E88.4), other specified metabolic disorders (E88.8), metabolic disorder, unspecified (E88.9) and wasting disease (syndrome) due to underlying condition (E88.A).

Use an additional code for adverse effect, if applicable, to identify drug (T45.1X5). Use an additional code for: codes for associated conditions.

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 673 (Other Kidney and Urinary Tract Procedures with MCC, relative weight 4.2525), DRG 674 (Other Kidney and Urinary Tract Procedures with CC, relative weight 2.2504), DRG 675 (Other Kidney and Urinary Tract Procedures without CC/MCC, relative weight 1.5887), DRG 682 (Renal Failure with MCC, relative weight 1.4656), DRG 683 (Renal Failure with CC, relative weight 0.8647), DRG 684 (Renal Failure without CC/MCC, relative weight 0.6003) and 2 more, in MDC 11 (Diseases and Disorders of the Kidney and Urinary Tract) and MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 277.88 (tumor lysis syndrome).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Tumor lysis syndrome (spontaneous)
  • Tumor lysis syndrome following antineoplastic drug chemotherapy
Use additional codeAdd a secondary code to fully describe the condition
  • code for adverse effect, if applicable, to identify drug (T45.1X5)

Notes that apply from higher levels

Instructions written at a parent level also apply to E88.3.

› From E88 Other and unspecified metabolic disorders
Excludes1
  • histiocytosis X (chronic) (C96.6)
Use additional code
  • codes for associated conditions

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

2 entries

Terms in the official ICD-10-CM index that lead to E88.3.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period

MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period

ICD-9-CM equivalent

Converter →
  • 277.88Tumor lysis syndromeexact

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E88.3

Is E88.3 billable?

Yes. E88.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E88.3 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E88.3 as a principal diagnosis.

Is E88.3 a CC or MCC?

E88.3 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does E88.3 group to?

E88.3 is used in the MS-DRG v44.0 logic for MS-DRG 673 (Other Kidney and Urinary Tract Procedures with MCC), MS-DRG 674 (Other Kidney and Urinary Tract Procedures with CC), MS-DRG 675 (Other Kidney and Urinary Tract Procedures without CC/MCC), MS-DRG 682 (Renal Failure with MCC), MS-DRG 683 (Renal Failure with CC), MS-DRG 684 (Renal Failure without CC/MCC) and 2 more. Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E88.3?

The CMS General Equivalence Mappings map E88.3 to ICD-9-CM 277.88.