ICD-10-CM 2027
ICD-10 code for metabolism disturbance
From the official ICD-10-CM alphabetic index entry “Disturbance (s) › metabolism”. Page updated September 29, 2026.
About coding metabolism disturbance
The ICD-10-CM code for metabolism disturbance is E88.9 (Metabolic disorder, unspecified). The official index lists 37 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E88.9.
Within E88, choose E88.9 (Metabolic disorder, unspecified) only when documentation doesn't support a more specific option: disorders of plasma-protein metabolism, not elsewhere classified (E88.0), lipodystrophy, not elsewhere classified (E88.1), Lipomatosis, not elsewhere classified (E88.2), tumor lysis syndrome (E88.3), mitochondrial metabolism disorders (E88.4), other specified metabolic disorders (E88.8) and wasting disease (syndrome) due to underlying condition (E88.A).
Use an additional code for: codes for associated conditions.
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific metabolism disturbance codes (official index)
- with
- abortion
- ectopic pregnancy O08.5 — Metabolic disorders following an ectopic and molar pregnancy
- molar pregnancy O08.5 — Metabolic disorders following an ectopic and molar pregnancy
- amino-acid E72.9 — Disorder of amino-acid metabolism, unspecified
- aromatic E70.9 — Disorder of aromatic amino-acid metabolism, unspecified
- branched-chain E71.2 — Disorder of branched-chain amino-acid metabolism, unspecified
- straight-chain E72.89 — Other specified disorders of amino-acid metabolism
- sulfur-bearing E72.10 — Disorders of sulfur-bearing amino-acid metabolism, unspecified
- ammonia E72.20 — Disorder of urea cycle metabolism, unspecified
- arginine E72.21 — Argininemia
- arginosuccinic acid E72.22 — Arginosuccinic aciduria
- carbohydrate E74.9 — Disorder of carbohydrate metabolism, unspecified
- cholesterol E78.9 — Disorder of lipoprotein metabolism, unspecified
- citrulline E72.23 — Citrullinemia
- cystathionine E72.19 — Other disorders of sulfur-bearing amino-acid metabolism
- general E88.9 — Metabolic disorder, unspecified
- glutamine E72.89 — Other specified disorders of amino-acid metabolism
- histidine E70.40 — Disorders of histidine metabolism, unspecified
- homocystine E72.19 — Other disorders of sulfur-bearing amino-acid metabolism
- hydroxylysine E72.3 — Disorders of lysine and hydroxylysine metabolism
- in labor or delivery O75.89 — Other specified complications of labor and delivery
- iron E83.10 — Disorder of iron metabolism, unspecified
- lipoid E78.9 — Disorder of lipoprotein metabolism, unspecified
- lysine E72.3 — Disorders of lysine and hydroxylysine metabolism
- methionine E72.19 — Other disorders of sulfur-bearing amino-acid metabolism
- neonatal, transitory P74.9 — Transitory metabolic disturbance of newborn, unspecified
- calcium and magnesium P71.9 — Transitory neonatal disorder of calcium and magnesium metabolism, unspecified
- specified type NEC P71.8 — Other transitory neonatal disorders of calcium and magnesium metabolism
- carbohydrate metabolism P70.9 — Transitory disorder of carbohydrate metabolism of newborn, unspecified
- specified type NEC P70.8 — Other transitory disorders of carbohydrate metabolism of newborn
- specified NEC P74.8 — Other transitory metabolic disturbances of newborn
- ornithine E72.4 — Disorders of ornithine metabolism
- phosphate E83.39 — Other disorders of phosphorus metabolism
- sodium NEC E87.8 — Other disorders of electrolyte and fluid balance, not elsewhere classified
- threonine E72.89 — Other specified disorders of amino-acid metabolism
- tryptophan E70.5 — Disorders of tryptophan metabolism
- tyrosine E70.20 — Disorder of tyrosine metabolism, unspecified
- urea cycle E72.20 — Disorder of urea cycle metabolism, unspecified
Common questions about metabolism disturbance ICD-10 codes
What is the ICD-10 code for metabolism disturbance?
- E88.9 — Metabolic disorder, unspecified. More specific codes apply when the documentation supports them: O08.5, O08.5, E72.9, E70.9 and others below.
What is the ICD-10 code for amino-acid metabolism disturbance?
- E72.9 — Disorder of amino-acid metabolism, unspecified.
What is the ICD-10 code for ammonia metabolism disturbance?
- E72.20 — Disorder of urea cycle metabolism, unspecified.
What is the ICD-10 code for arginine metabolism disturbance?
- E72.21 — Argininemia.
What is the ICD-10 code for arginosuccinic acid metabolism disturbance?
- E72.22 — Arginosuccinic aciduria.
What is the ICD-10 code for carbohydrate metabolism disturbance?
- E74.9 — Disorder of carbohydrate metabolism, unspecified.
What is the ICD-10 code for cholesterol metabolism disturbance?
- E78.9 — Disorder of lipoprotein metabolism, unspecified.
Is E88.9 billable?
- Yes. E88.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E88.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E88.9 as a principal diagnosis.
Is E88.9 a CC or MCC?
- No. E88.9 is neither a CC nor an MCC under MS-DRG v44.0.