ICD-10-CM 2027 diagnosis code
E78.00Pure hypercholesterolemia, unspecified
E78.00 is a valid, billable ICD-10-CM code for pure hypercholesterolemia, unspecified. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Looking up by condition? See ICD-10 code for Cholesteremia, ICD-10 code for Cholesterolemia, ICD-10 code for Hypercholesterolemia, ICD-10 code for Hyperbetalipoproteinemia.
Code last changed in FY2017 (effective October 1, 2016). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About E78.00
E78.00 is the ICD-10-CM diagnosis code for pure hypercholesterolemia, unspecified. It belongs to category E78 (disorders of lipoprotein metabolism and other lipidemias), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within E78.0, choose E78.00 (unspecified) only when documentation doesn't support a more specific option: familial hypercholesterolemia (E78.01).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It was added in FY2017, effective October 1, 2016.
Before ICD-10, this condition was coded in ICD-9-CM as 272.0 (pure hypercholesterolemia).
Coding notes
- Fredrickson's hyperlipoproteinemia, type IIa
- Hyperbetalipoproteinemia
- Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
- (Pure) hypercholesterolemia NOS
Notes that apply from higher levels
Instructions written at a parent level also apply to E78.00.
Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.
Alphabetic index entries
15 entriesTerms in the official ICD-10-CM index that lead to E78.00.
- Cholesteremia
- Cholesterol › elevated (high)
- Cholesterolemia (essential) (pure)
- Elevated, elevation › cholesterol
- Findings, abnormal, inconclusive, without diagnosis › cholesterol › high
- Frederickson's hyperlipoproteinemia, type › IIA
- High › cholesterol
- Hyperbetalipoproteinemia (familial)
- Hypercholesterolemia (essential) (primary) (pure)
- Hyperlipemia, hyperlipidemia › group › A
- Hyperlipoproteinemia › Fredrickson's type › IIa
- Hyperlipoproteinemia › low-density-lipoprotein-type (LDL)
- Low-density-lipoprotein-type (LDL) hyperlipoproteinemia
- Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › hypercholesterinemic
- Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › hypercholesterolemic
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders
ICD-9-CM equivalent
Converter →- 272.0Pure hypercholesterolemiaapproximate
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2017 (effective 10/1/2016): Added
- No changes since FY2017.
Common questions about E78.00
Is E78.00 billable?
- Yes. E78.00 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E78.00 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E78.00 as a principal diagnosis.
Is E78.00 a CC or MCC?
- No. E78.00 is neither a CC nor an MCC under MS-DRG v44.0.
What DRG does E78.00 group to?
- E78.00 is used in the MS-DRG v44.0 logic for MS-DRG 642 (Inborn and Other Disorders of Metabolism). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for E78.00?
- The CMS General Equivalence Mappings map E78.00 to ICD-9-CM 272.0.