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ICD-10-CM 2027 diagnosis code

E78.5Hyperlipidemia, unspecified

✓ Billable / specific

E78.5 is a valid, billable ICD-10-CM code for hyperlipidemia, unspecified. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS, effective October 1, 2026. Updated September 29, 2026. About our data

About E78.5

E78.5 is the ICD-10-CM diagnosis code for hyperlipidemia, unspecified. It belongs to category E78 (disorders of lipoprotein metabolism and other lipidemias), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E78, choose E78.5 (Hyperlipidemia, unspecified) only when documentation doesn't support a more specific option: pure hypercholesterolemia (E78.0), pure hyperglyceridemia (E78.1), mixed hyperlipidemia (E78.2), Hyperchylomicronemia (E78.3), other hyperlipidemia (E78.4), lipoprotein deficiency (E78.6), disorders of bile acid and cholesterol metabolism (E78.7), other disorders of lipoprotein metabolism (E78.8) and 1 more.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 272.4 (other and unspecified hyperlipidemia).

Notes that apply from higher levels

Instructions written at a parent level also apply to E78.5.

› From E78 Disorders of lipoprotein metabolism and other lipidemias
Excludes1

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

5 entries

Terms in the official ICD-10-CM index that lead to E78.5.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders

ICD-9-CM equivalent

Converter →
  • 272.4Other and unspecified hyperlipidemiaapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E78.5

Is E78.5 billable?

Yes. E78.5 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E78.5 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E78.5 as a principal diagnosis.

Is E78.5 a CC or MCC?

No. E78.5 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E78.5 group to?

E78.5 is used in the MS-DRG v44.0 logic for MS-DRG 642 (Inborn and Other Disorders of Metabolism). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E78.5?

The CMS General Equivalence Mappings map E78.5 to ICD-9-CM 272.4.